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pentobarbital will reduce the level or effect of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to your lessen in fentanyl plasma concentrations, lack of efficacy or, possibly, development of a withdrawal syndrome in a very affected in